Evidence for Involvement of Protein Kinase C in Expression of Intracellular Adhesion Molecule-1 (ICAM-1) by Human Vascular Endothelial Cells
| Autor: | Cheng-Po Sung, Ponnal Nambi, Anthony J. Arleth |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharides
Indoles Lactams Intercellular Adhesion Molecule-1 Biology Mitogen-activated protein kinase kinase Piperazines Umbilical vein 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Humans Protein Kinase Inhibitors Cells Cultured Phorbol 12 13-Dibutyrate Protein Kinase C Protein kinase C Pharmacology ICAM-1 Tumor Necrosis Factor-alpha Cell adhesion molecule General Medicine Isoquinolines Up-Regulation Cell biology Vascular endothelial growth factor A Endothelium Vascular Cell Adhesion Molecules Cell Division |
| Zdroj: | Pharmacology. 48:143-146 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000139173 |
| Popis: | Potent activators of protein kinase C (PKC), such as phorbol dibutyrate and octylindolactam V, stimulated expression of intercellular adhesion molecule 1 (ICAM-1) by human umbilical vein endothelial cells (HUVEC) in a concentration-dependent manner. Expression of PKC activator-induced ICAM-1 in HUVEC was inhibited by the PKC inhibitor, H-7. Furthermore, cytokine (TNF alpha, LPS)-induced ICAM-1 expression was inhibited by the potent PKC inhibitor, H-7, and not by the cAMP-dependent protein kinase (PKA) specific inhibitor, H-89. These data suggest that PKC is involved in cytokine- and inflammatory agent-induced upregulation of ICAM-1 expression in HUVEC. |
| Databáze: | OpenAIRE |
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