Clinical importance of serum procalcitonin in ulcerative colitis patients
Autor: | Shigeo Koido, Toshifumi Ohkusa, Mikio Kajihara, Hiroshi Arakawa, Hisao Tajiri, Jimi Mitobe, Kazuki Takakura, Shintaro Tsukinaga, Shunichi Odahara, Toyokazu Yukawa, Kan Uchiyama |
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Rok vydání: | 2014 |
Předmět: |
Male
Severity of Illness Index Gastroenterology Procalcitonin Leukocyte Count Healthy volunteers Prospective Studies biology medicine.diagnostic_test Colonoscopy General Medicine Middle Aged Prognosis Ulcerative colitis Up-Regulation medicine.anatomical_structure C-Reactive Protein Erythrocyte sedimentation rate Female hormones hormone substitutes and hormone antagonists Adult Calcitonin congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Brief Article Calcitonin Gene-Related Peptide Blood Sedimentation Letters To The Editor Disease activity Young Adult Predictive Value of Tests White blood cell Internal medicine parasitic diseases Remission phase medicine Humans In patient Clinical significance Protein Precursors business.industry C-reactive protein bacterial infections and mycoses medicine.disease digestive system diseases Surgery Case-Control Studies Immunology biology.protein Colitis Ulcerative business Biomarkers |
Zdroj: | World Journal of Gastroenterology. 20:15941 |
ISSN: | 1007-9327 |
Popis: | AIM: To investigate the association of procalcitonin (PCT) with ulcerative colitis (UC) activity. METHODS: Serum PCT levels, C-reactive protein (CRP) levels, the erythrocyte sedimentation rate, and the white blood cell count were analyzed in 18 patients with UC and 11 healthy volunteers. Serum PCT levels were analyzed by an electrochemiluminescence immunoassay. Severity assessments were based on Truelove and Witts’ severity index. Correlation of serum PCT and CRP levels with UC activity was examined. Moreover, we assessed serum PCT and CRP levels in patients with a Mayo endoscopic subscore. RESULTS: Serum PCT levels in severe UC patients (n = 7) (0.096 ± 0.034 ng/mL) were significantly higher than in mild-to-moderate UC patients (n = 11) (0.033 ± 0.012 ng/mL) and healthy volunteers (n = 11) (0.035 ± 0.005 ng/mL) (P = 0.0005 and P < 0.0001, respectively). In addition, there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy volunteers. Interestingly, patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT (0.075 ± 0.043 ng/mL) compared with patients with a subscore of 2 points (0.03 ± 0.011 ng/mL) (P = 0.0302). Moreover, CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 points. CONCLUSION: Serum PCT levels were significantly correlated with UC activity. |
Databáze: | OpenAIRE |
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