Clinical importance of serum procalcitonin in ulcerative colitis patients

Autor: Shigeo Koido, Toshifumi Ohkusa, Mikio Kajihara, Hiroshi Arakawa, Hisao Tajiri, Jimi Mitobe, Kazuki Takakura, Shintaro Tsukinaga, Shunichi Odahara, Toyokazu Yukawa, Kan Uchiyama
Rok vydání: 2014
Předmět:
Male
Severity of Illness Index
Gastroenterology
Procalcitonin
Leukocyte Count
Healthy volunteers
Prospective Studies
biology
medicine.diagnostic_test
Colonoscopy
General Medicine
Middle Aged
Prognosis
Ulcerative colitis
Up-Regulation
medicine.anatomical_structure
C-Reactive Protein
Erythrocyte sedimentation rate
Female
hormones
hormone substitutes
and hormone antagonists
Adult
Calcitonin
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Brief Article
Calcitonin Gene-Related Peptide
Blood Sedimentation
Letters To The Editor
Disease activity
Young Adult
Predictive Value of Tests
White blood cell
Internal medicine
parasitic diseases
Remission phase
medicine
Humans
In patient
Clinical significance
Protein Precursors
business.industry
C-reactive protein
bacterial infections and mycoses
medicine.disease
digestive system diseases
Surgery
Case-Control Studies
Immunology
biology.protein
Colitis
Ulcerative
business
Biomarkers
Zdroj: World Journal of Gastroenterology. 20:15941
ISSN: 1007-9327
Popis: AIM: To investigate the association of procalcitonin (PCT) with ulcerative colitis (UC) activity. METHODS: Serum PCT levels, C-reactive protein (CRP) levels, the erythrocyte sedimentation rate, and the white blood cell count were analyzed in 18 patients with UC and 11 healthy volunteers. Serum PCT levels were analyzed by an electrochemiluminescence immunoassay. Severity assessments were based on Truelove and Witts’ severity index. Correlation of serum PCT and CRP levels with UC activity was examined. Moreover, we assessed serum PCT and CRP levels in patients with a Mayo endoscopic subscore. RESULTS: Serum PCT levels in severe UC patients (n = 7) (0.096 ± 0.034 ng/mL) were significantly higher than in mild-to-moderate UC patients (n = 11) (0.033 ± 0.012 ng/mL) and healthy volunteers (n = 11) (0.035 ± 0.005 ng/mL) (P = 0.0005 and P < 0.0001, respectively). In addition, there was no difference in serum PCT levels between mild-to-moderate UC patients and healthy volunteers. Interestingly, patients with a Mayo endoscopic subscore of 3 points displayed significantly increased levels of serum PCT (0.075 ± 0.043 ng/mL) compared with patients with a subscore of 2 points (0.03 ± 0.011 ng/mL) (P = 0.0302). Moreover, CRP levels in patients with severe UC or a Mayo endoscopic subscore of 3 points were not significantly higher than in patients with mild-to-moderate UC or a Mayo endoscopic subscore of 3 points. CONCLUSION: Serum PCT levels were significantly correlated with UC activity.
Databáze: OpenAIRE
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