Renewal of nucleotides and nucleic acids in C57 mice studied with adenine-4,6-14C1
| Autor: | Barbara J. Krueckel, Edward L. Bennett |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
chemistry.chemical_classification
Biochemical Phenomena Nucleotides Adenine Research Nucleic acid sequence Adenine phosphoribosyltransferase RNA General Medicine Biology Molecular biology Mice chemistry.chemical_compound chemistry Biochemistry Adenine nucleotide Nucleic Acids Nucleic acid Animals Nucleotide Nucleic acid structure DNA |
| Zdroj: | Biochimica et Biophysica Acta. 17:503-514 |
| ISSN: | 0006-3002 |
| Popis: | Adenine has been shown to be extensively utilized for formation of acid-soluble adenine nucleotides and for formation of RNA and DNA in C57 mice. The “apparent half-lives” of adenine in nucleotides, RNA and DNA of the organs of the mouse have been calculated, and a “fast”- and a “slow”-component adenine were found in the adenine-containing fractions in several tissues. Evidence is presented that soluble adenine nucleotides serve as precursors for RNA and DNA, and that the equilibration of nucleotides with RNA is relatively rapid in large and small intestines and probably also in bone marrow. The desirability of more extensive data for nucleotide and nucleic acid specific activity as a function of time with several precursors is emphasized. |
| Databáze: | OpenAIRE |
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