Renewal of nucleotides and nucleic acids in C57 mice studied with adenine-4,6-14C1

Autor: Barbara J. Krueckel, Edward L. Bennett
Rok vydání: 1955
Předmět:
Zdroj: Biochimica et Biophysica Acta. 17:503-514
ISSN: 0006-3002
Popis: Adenine has been shown to be extensively utilized for formation of acid-soluble adenine nucleotides and for formation of RNA and DNA in C57 mice. The “apparent half-lives” of adenine in nucleotides, RNA and DNA of the organs of the mouse have been calculated, and a “fast”- and a “slow”-component adenine were found in the adenine-containing fractions in several tissues. Evidence is presented that soluble adenine nucleotides serve as precursors for RNA and DNA, and that the equilibration of nucleotides with RNA is relatively rapid in large and small intestines and probably also in bone marrow. The desirability of more extensive data for nucleotide and nucleic acid specific activity as a function of time with several precursors is emphasized.
Databáze: OpenAIRE