Serum, liver and bile sitosterol and sitostanol in obese patients with and without NAFLD
| Autor: | Pirjo Käkelä, Vesa Kärjä, Sari Venesmaa, Maija Vaittinen, Milla-Maria Tauriainen, Helena Gylling, Jussi Pihlajamäki, Ville Männistö, Dorota Kaminska |
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| Přispěvatelé: | Department of Medicine, Clinicum, HUS Internal Medicine and Rehabilitation, HUS Abdominal Center |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Biophysics Inflammation METABOLISM BILIARY Biochemistry DISEASE 03 medical and health sciences chemistry.chemical_compound INFLAMMATION Internal medicine Medicine Molecular Biology GENE-EXPRESSION 2. Zero hunger beta-Sitosterol PLANT STEROLS business.industry Cholesterol NONALCOHOLIC STEATOHEPATITIS Fatty liver STANOL ESTERS Cell Biology BETA-SITOSTEROL medicine.disease Sterol transport CHOLESTEROL ABSORPTION 3. Good health 030104 developmental biology Endocrinology chemistry 1182 Biochemistry cell and molecular biology lipids (amino acids peptides and proteins) 3111 Biomedicine Steatosis Steatohepatitis medicine.symptom business Body mass index |
| Popis: | Background and aims: Non-alcoholic fatty liver disease (NAFLD) associates with low levels of serum plant sterols in cross-sectional studies. In addition, it has been suggested that the hepatic sterol transport mechanisms are altered in NAFLD. Therefore, we investigated the association between serum, liver and bile plant sterols and sitostanol with NAFLD.: MethodsOut of the 138 individuals (age: 46.3 ± 8.9, body mass index: 43.3 ± 6.9 kg/m², 28% men and 72% women), 44 could be histologically categorized to have normal liver, and 94 to have NAFLD. Within the NAFLD group, 28 had simple steatosis and 27 had non-alcoholic steatohepatitis. Plant sterols and sitostanol were measured from serum (n=138), liver (n=38), and bile (n=41). The mRNA expression of genes regulating liver sterol metabolism and inflammation was measured (n=102).: ResultsLiver and bile sitostanol ratios to cholesterol were higher in those with NAFLD compared to those with histologically normal liver (all P 0.407, P ConclusionOur study showed that liver and bile sitostanol ratios to cholesterol associated positively and liver sitosterol ratio to cholesterol associated negatively with liver steatosis and inflammation in obese individuals with NAFLD.. |
| Databáze: | OpenAIRE |
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