Prior exercise protects against oxidative stress and motor deficit in a rat model of Parkinson's disease
| Autor: | Kátia Simone Kietzer, Victor Douglas Pereira Silva de Oliveira, Mariseth Carvalho de Andrade, Jofre Jacob da Silva Freitas, Leonam Oliver Durval Oliveira, Raphaely Cristiny Sanches Progênio, Renata Cunha Silva, Renato Pereira Rodrigues Filho, Pedro Iuri Castro da Silva |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Parkinson's disease Thiobarbituric acid Substantia nigra Physical exercise Striatum medicine.disease_cause Biochemistry Lesion 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound Random Allocation 0302 clinical medicine Parkinsonian Disorders Internal medicine Physical Conditioning Animal medicine Animals Rats Wistar Oxidopamine business.industry medicine.disease Rats Motor Skills Disorders Oxidative Stress 030104 developmental biology Endocrinology nervous system chemistry Neurology (clinical) medicine.symptom business Motor Deficit 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Metabolic brain disease. 35(1) |
| ISSN: | 1573-7365 |
| Popis: | This study investigated if a prior long-term physical exercise protocol protects the substantia nigra and the striatum against oxidative stress and motor deficits in a Parkinson Disease model induced by 6-hydroxydopamine. Three animal treatment groups were included in the study: sham; 6-hydroxydopamine and 6-hydroxydopamine/exercise. Previously to the intrastriatal lesion by 6-hydroxydopamine, rats in the exercise groups performed a swimming program for 18 weeks. The rats were submitted to behavioral tests before and after intrastriatal 6-hydroxydopamine injection. The oxidative stress was analyzed by Thiobarbituric Acid Reactive Substances and Glutathione reductase activity methods. The exercise decreased lipid peroxidation and increased glutathione reductase activity in the substantia nigra. In contrast, in the striatum, exercise increased lipid peroxidation and decreased glutathione reductase activity. Exercise increased contralateral rotations and reduces immobility levels at 14 days post lesion. The exercise prior to 6-OHDA lesion had protective action only in substantia nigra against oxidative stress. |
| Databáze: | OpenAIRE |
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