The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury
| Autor: | Majid Assadi, Firoozeh Dehdar, Mohammad Seyedabadi, Abdolhamid Esmaeeli, Zahra Keshavarz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
G protein
Health Toxicology and Mutagenesis medicine.medical_treatment Adrenergic beta-Antagonists Propranolol 010501 environmental sciences Pharmacology Kidney Toxicology 01 natural sciences Nephrotoxicity 03 medical and health sciences 0302 clinical medicine Animals Medicine Receptor Carvedilol 0105 earth and related environmental sciences Desensitization (medicine) Metoprolol Cisplatin Chemical Health and Safety business.industry Public Health Environmental and Occupational Health General Medicine Rats Creatinine Technetium Tc 99m Dimercaptosuccinic Acid business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Drug and Chemical Toxicology. 45:1558-1564 |
| ISSN: | 1525-6014 0148-0545 |
| Popis: | The β-adrenoceptor blockers may have anti-oxidant properties or induce β-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol, metoprolol and propranolol in an animal model of cisplatin-induced nephrotoxicity. Rats received the β-blockers (3 or 12 mg/kg/day) with or without cisplatin, and kidney function was investigated using renal scintigraphy, histopathology, and serum variables. Metoprolol and propranolol as well as low-dose carvedilol did not alter kidney function, per se. Meanwhile, high-dose carvedilol reduced renal accumulation of Technetium-99m (99mTc)-labeled dimercaptosuccinic acid (99mTc-DMSA) without significant effect on other variables. Furthermore, low-dose carvedilol prevented cisplatin-induced reduction of tracer uptake, but high-dose of this drug aggravated the situation. In this regard, both low and high -doses of carvedilol significantly inhibited cisplatin effects on kidney histology, BUN and creatinine levels. Also, high-dose propranolol inhibited cisplatin adverse effects on radiotracer uptake, histological manifestations, BUN and creatinine levels, while metoprolol failed to cause a notable effect. Taken together, carvedilol and high-dose propranolol may offer potential benefits in cisplatin nephrotoxicity. |
| Databáze: | OpenAIRE |
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