Exercise modifies amphetamine relapse: behavioral and oxidative markers in rats
| Autor: | Kr. Roversi, Camila Simonetti Pase, H.J. Segat, Katiane Roversi, Marilise Escobar Burger, Luciana Taschetto Vey, A.J. Schuster, Caren Tatiane de David Antoniazzi, Maikel Kronbauer |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Elevated plus maze medicine.medical_specialty media_common.quotation_subject Amphetamine-Related Disorders Physical exercise Anxiety Hippocampus Behavioral Neuroscience Internal medicine Physical Conditioning Animal Neuroplasticity Conditioning Psychological medicine Secondary Prevention Hippocampus (mythology) Animals Rats Wistar Amphetamine Psychiatry media_common Addiction Abstinence Catalase Conditioned place preference Rats Oxidative Stress Endocrinology Sodium-Potassium-Exchanging ATPase Psychology Biomarkers medicine.drug |
| Zdroj: | Behavioural brain research. 262 |
| ISSN: | 1872-7549 |
| Popis: | Exercise has been reported to attenuate rewarding symptoms related to addictive drugs mainly by affecting the brain neuroplasticity and neurotransmission. In this study, we investigated the influence of physical exercise on the behavioral and enzymatic status related to drug relapse in rats. Animals were primarily treated with amphetamine (AMPH; 4.0 mg/kg, i.p.) or vehicle (C; NaCl 0.9% solution) in the conditioned place preference (CPP) paradigm for 14 days. Half of each experimental group was then submitted to swimming sessions (60 min/day, 5 days/week) for 5 weeks. Animals were re-exposed to AMPH- or vehicle-CPP paradigm for another 3 days, in order to observe drug relapse and anxiety-like symptoms, which were observed 24h after AMPH reconditioning in CPP, and elevated plus maze (EPM), respectively, and brain biochemical evaluations were carried out subsequently. While AMPH was related to place preference and anxiety, indicating drug addiction and abstinence symptoms, respectively, physical activity was able to prevent relapse symptoms after AMPH reconditioning, as observed through consecutive decreased CPP and anxiety-like symptoms. In addition, AMPH exposure increased reactive species (RS) generation and protein carbonyl (PC) levels together with decreased activity of catalase- and Na(+)K(+)-ATPase in hippocampus. On the other hand, while all AMPH-induced effects were prevented by physical activity, there was a negative correlation between PC levels (r=0.65; p |
| Databáze: | OpenAIRE |
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