Dietary Flavonoids in p53-Mediated Immune Dysfunctions Linking to Cancer Prevention
| Autor: | Cijo George Vazhappilly, Shoib S. Siddiqui, H.P. Vasantha Rupasinghe, Sofia Rahman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
p53
medicine.medical_treatment Medicine (miscellaneous) Inflammation Review Biology medicine.disease_cause Major histocompatibility complex General Biochemistry Genetics and Molecular Biology Immune system Cancer immunotherapy medicine lcsh:QH301-705.5 Cancer prevention cancer prevention anti-oxidant Nrf2 pathway Cancer medicine.disease KEAP1 lcsh:Biology (General) inflammation flavonoids biology.protein Cancer research medicine.symptom Carcinogenesis |
| Zdroj: | Biomedicines Biomedicines, Vol 8, Iss 286, p 286 (2020) |
| ISSN: | 2227-9059 |
| Popis: | The p53 protein plays a central role in mediating immune functioning and determines the fate of the cells. Its role as a tumor suppressor, and in transcriptional regulation and cytokine activity under stress conditions, is well defined. The wild type (WT) p53 functions as a guardian for the genome, while the mutant p53 has oncogenic roles. One of the ways that p53 combats carcinogenesis is by reducing inflammation. WT p53 functions as an anti-inflammatory molecule via cross-talk activity with multiple immunological pathways, such as the major histocompatibility complex I (MHCI) associated pathway, toll-like receptors (TLRs), and immune checkpoints. Due to the multifarious roles of p53 in cancer, it is a potent target for cancer immunotherapy. Plant flavonoids have been gaining recognition over the last two decades to use as a potential therapeutic regimen in ameliorating diseases. Recent studies have shown the ability of flavonoids to suppress chronic inflammation, specifically by modulating p53 responses. Further, the anti-oxidant Keap1/Nrf2/ARE pathway could play a crucial role in mitigating oxidative stress, leading to a reduction of chronic inflammation linked to the prevention of cancer. This review aims to discuss the pharmacological properties of plant flavonoids in response to various oxidative stresses and immune dysfunctions and analyzes the cross-talk between flavonoid-rich dietary intake for potential disease prevention. |
| Databáze: | OpenAIRE |
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