Lyophilized glutaraldehyde-preserved bovine pericardium for experimental atrial septal defect closure

Autor: M. Baltazares-Lipp, Aboitiz-Rivera C, J. Villalba-Caloca, J.A. Santibañez-Salgado, Pérez-Covarrubias D, Olmos-Zúñiga, Jasso-Victoria R, Miguel Gaxiola-Gaxiola, Pérez-López M, Sotres-Vega A
Rok vydání: 2010
Předmět:
lcsh:Diseases of the musculoskeletal system
Tissue Fixation
Biocompatible Materials
Heart Septal Defects
Atrial
Intracardiac injection
chemistry.chemical_compound
Postoperative Complications
Materials Testing
Heart Septum
Normal heart
lyophilizated bioprostheses
Heart septal defect
Polyethylene Terephthalates
biological biomaterials
Prostheses and Implants
animal models
Treatment Outcome
Echocardiography
scaffolds
cardiovascular system
Collagen
Pericardium
medicine.medical_specialty
Bovine pericardium
lcsh:Surgery
cardiovascular tissue
Atrial septal defects
Prosthesis Implantation
Fixatives
Dogs
medicine
Animals
atrial septal defect
cardiovascular diseases
Cardiac Surgical Procedures
Thrombus
business.industry
lcsh:RD1-811
Atrial septal defect closure
bovine pericardium
medicine.disease
Surgery
Disease Models
Animal
Cartilage
Freeze Drying
chemistry
Glutaral
In vivo biocompatibility
Cattle
Glutaraldehyde
lcsh:RC925-935
business
Zdroj: European Cells & Materials, Vol 19, Pp 158-165 (2010)
DOI: 10.22203/ecm.v019a16
Popis: A variety of patch materials has been used to close large atrial septal defects (ASD). Autologous pericardium and glutaraldehyde-preserved bovine pericardium are the most used. Lyophilized bovine pericardium has not been tested inside the cardiovascular system. The aim of this work was to study the behaviour and effectiveness of lyophilized glutaraldehyde-preserved bovine pericardium in ASD closure. Sixteen mongrel dogs were operated on. A 3 cm diameter atrial septal defect was created, and closed with: Group I (n=8): Lyophilized glutaraldehyde preserved bovine pericardium (LGPBP). Group II (n=8): Vascular Dacron patch. The animals were evaluated clinically, by echocardiography, macroscopically, and microscopically. Statistical analysis was done with analysis of variance (ANOVA) and Student’s t-test. All the animals survived the surgical procedure and study time (6 months). Clinically all the animals displayed normal physical activity, with normal cardiac sounds. Echocardiography showed that both groups had a normal heart without intracardiac shunts, no thrombus formation, and no vegetations. Macroscopically all the animals showed good integration of the lyophilized bioprosthesis and Dacron patch. All group I animals presented a decrease of the area of the ASD in the left atrium (p
Databáze: OpenAIRE
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