Isolation and structure elucidation of five new asterriquinones from Aspergillus, Humicola and Botryotrichum species
| Autor: | Ursula Mocek, Uma Sinha, Jerry J. Nzerem, Larry Fretto, Tim Buchan, Lauri Schultz, Louis Sehl, Charles Baek |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Indole test Aspergillus Proteases Indoles Magnetic Resonance Spectroscopy Serine Proteinase Inhibitors Molecular Structure Stereochemistry Fungi Quinones Fungi imperfecti Biology Spectrometry Mass Fast Atom Bombardment biology.organism_classification Quinone Serine Biochemistry Drug Discovery Moiety Mitosporic Fungi Blood Coagulation Soil Microbiology |
| Zdroj: | The Journal of antibiotics. 49(9) |
| ISSN: | 0021-8820 |
| Popis: | Five new quinone pigments have been discovered from the fermentation broth of Aspergillus, Humicola and Botryotrichum species isolated from different soil samples. These compounds inhibit serine proteases of the coagulation pathway. Their structures which differ in the identity and position of a 5-carbon side chain on the indole moiety have been elucidated based on NMR and FAB-MS experiments. |
| Databáze: | OpenAIRE |
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