The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila

Autor: Pierre Léopold, Nathalie Arquier, Sophie Layalle
Přispěvatelé: Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)
Rok vydání: 2008
Předmět:
MESH: Signal Transduction
Ecdysone
Time Factors
MESH: Drosophila
MESH: Drosophila Proteins
Period (gene)
Models
Biological
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drosophilidae
Animals
Drosophila Proteins
MESH: Animals
[SDV.BDD]Life Sciences [q-bio]/Development Biology
Molecular Biology
Drosophila
030304 developmental biology
Sirolimus
0303 health sciences
biology
Ecology
MESH: Time Factors
MESH: Models
Biological
MESH: Immunohistochemistry
Cell Biology
biology.organism_classification
Prothoracic gland
Immunohistochemistry
Cell biology
TOR signaling
MESH: Ecdysone
chemistry
Food
Larva
CELLBIO
MESH: Sirolimus
Drosophila melanogaster
MESH: Larva
MESH: Food
030217 neurology & neurosurgery
Signal Transduction
Developmental Biology
Pupariation
Zdroj: Developmental Cell
Developmental Cell, Elsevier, 2008, 15 (4), pp.568-77. ⟨10.1016/j.devcel.2008.08.003⟩
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2008.08.003
Popis: International audience; In many metazoans, final adult size depends on the growth rate and the duration of the growth period, two parameters influenced by nutritional cues. We demonstrate that, in Drosophila, nutrition modifies the timing of development by acting on the prothoracic gland (PG), which secretes the molting hormone ecdysone. When activity of the Target of Rapamycin (TOR), a core component of the nutrient-responsive pathway, is reduced in the PG, the ecdysone peak that marks the end of larval development is abrogated. This extends the duration of growth and increases animal size. Conversely, the developmental delay caused by nutritional restriction is reversed by activating TOR solely in PG cells. Finally, nutrition acts on the PG during a restricted time window near the end of larval development that coincides with the commitment to pupariation. In conclusion, the PG uses TOR signaling to couple nutritional input with ecdysone production and developmental timing.
Databáze: OpenAIRE
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