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Additional file 1: Supplementary Figure 1 Effects of endothelin administration on the expression of inhibitory and co-stimulatory molecules on monocytes (CD11b+) in the CNS of infected mice. The percentage of inhibitory (PDL-1) and co-stimulatory molecules (CD40, CD80, CD86, and MHC) expressed on CNS CD11b+ cells among the total CNS CD11b+ cells from TMEV-infected mice treated with either PBS or ET-1 (each, n = 3) at 8 dpi (mean ± SD). Data are representative of three independent experiments. *, p < 0.05, and **, p < 0.001. Supplementary Figure 2. Effect of endothelin receptor antagonist treatment on PLP-induced EAE. Mice (n=5/group) was immunized with optimal dose (40 μg PLP) and treated with PBS (cont), BQ610, or BQ788 (1 mg/kg) at 0, 5, 10, 15, 20, 30, and 46 dpi. The disease course was determined using the 5-point scale. BQ788 treated group was significantly (p |
