Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition
Autor: | Kay-Tee Khaw, Kim Overvad, Petra H.M. Peeters, Pagona Lagiou, Antonia Trichopoulou, Anne M. May, Bodil Ohlsson, Peter D. Siersema, Pietro Ferrari, Heiner Boeing, Heinz Freisling, Tobias Pischon, Krasimira Aleksandrova, Androniki Naska, H. Bas Bueno-de-Mesquita, Timothy J. Key, Brian Buijsse, Elio Riboli, Christina C. Dahm, Valeria Pala, Mazda Jenab, Amalia Mattiello, Karin Jirström, Anne Tjønneland, Veronika Fedirko |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Time Factors Colorectal cancer Nutritional Status Weight Gain Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Prospective Studies skin and connective tissue diseases Prospective cohort study Adiposity Proportional Hazards Models 030304 developmental biology 2. Zero hunger Gynecology 0303 health sciences Cancer prevention business.industry Incidence Weight change Hazard ratio Age Factors Cancer Middle Aged medicine.disease digestive system diseases 3. Good health European Prospective Investigation into Cancer and Nutrition Europe Oncology Obesity Abdominal 030220 oncology & carcinogenesis Multivariate Analysis Linear Models Female sense organs Waist Circumference Colorectal Neoplasms business Risk Reduction Behavior Body mass index |
Zdroj: | Aleksandrova, K, Pischon, T, Buijsse, B, May, A M, Peeters, P H, Bueno-de-Mesquita, H B, Jenab, M, Fedirko, V, Dahm, C C, Siersema, P D, Freisling, H, Ferrari, P, Overvad, K, Tjønneland, A, Trichopoulou, A, Lagiou, P, Naska, A, Pala, V, Mattiello, A, Ohlsson, B, Jirström, K, Key, T J, Khaw, K-T, Riboli, E & Boeing, H 2013, ' Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition ', European Journal of Cancer, vol. 49, no. 16, pp. 3526-3536 . https://doi.org/10.1016/j.ejca.2013.06.021 |
ISSN: | 1879-0852 0959-8049 |
Popis: | Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P-interaction = 0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95% CI 1.14-2.91, P-interaction = 0.02). Results were not different in men and women (P-interaction = 0.81). Conclusion(s): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention. (C) 2013 Elsevier Ltd. All rights reserved. (Less) |
Databáze: | OpenAIRE |
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