Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Autor: Kay-Tee Khaw, Kim Overvad, Petra H.M. Peeters, Pagona Lagiou, Antonia Trichopoulou, Anne M. May, Bodil Ohlsson, Peter D. Siersema, Pietro Ferrari, Heiner Boeing, Heinz Freisling, Tobias Pischon, Krasimira Aleksandrova, Androniki Naska, H. Bas Bueno-de-Mesquita, Timothy J. Key, Brian Buijsse, Elio Riboli, Christina C. Dahm, Valeria Pala, Mazda Jenab, Amalia Mattiello, Karin Jirström, Anne Tjønneland, Veronika Fedirko
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Adult
Male
Cancer Research
medicine.medical_specialty
Time Factors
Colorectal cancer
Nutritional Status
Weight Gain
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Prospective Studies
skin and connective tissue diseases
Prospective cohort study
Adiposity
Proportional Hazards Models
030304 developmental biology
2. Zero hunger
Gynecology
0303 health sciences
Cancer prevention
business.industry
Incidence
Weight change
Hazard ratio
Age Factors
Cancer
Middle Aged
medicine.disease
digestive system diseases
3. Good health
European Prospective Investigation into Cancer and Nutrition
Europe
Oncology
Obesity
Abdominal
030220 oncology & carcinogenesis
Multivariate Analysis
Linear Models
Female
sense organs
Waist Circumference
Colorectal Neoplasms
business
Risk Reduction Behavior
Body mass index
Zdroj: Aleksandrova, K, Pischon, T, Buijsse, B, May, A M, Peeters, P H, Bueno-de-Mesquita, H B, Jenab, M, Fedirko, V, Dahm, C C, Siersema, P D, Freisling, H, Ferrari, P, Overvad, K, Tjønneland, A, Trichopoulou, A, Lagiou, P, Naska, A, Pala, V, Mattiello, A, Ohlsson, B, Jirström, K, Key, T J, Khaw, K-T, Riboli, E & Boeing, H 2013, ' Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition ', European Journal of Cancer, vol. 49, no. 16, pp. 3526-3536 . https://doi.org/10.1016/j.ejca.2013.06.021
ISSN: 1879-0852
0959-8049
Popis: Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P-interaction = 0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95% CI 1.14-2.91, P-interaction = 0.02). Results were not different in men and women (P-interaction = 0.81). Conclusion(s): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
Databáze: OpenAIRE
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