Spinogenesis and Plastic Changes in the Dendritic Spines of Spinal Cord Motoneurons After Traumatic Injury in Rats
| Autor: | Eliseo Portilla-de Buen, Néstor I. Martínez Torres, Stephanie Sánchez-Torres, David González-Tapia, Nallely Vázquez-Hernández, Laura Alvarez-Mejia, Rodrigo Mondragón-Lozano, Omar Fabela-Sánchez, Myrna M. González-Ramírez, Ignacio González-Burgos, Caridad Leal-Cortés, Hermelinda Salgado-Ceballos |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Dendritic spine medicine.medical_treatment Dendritic Spines Thoracic Vertebrae Lesion Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Animals Rats Long-Evans Spinal cord injury Spinal Cord Injuries Motor Neurons Wound Healing Neuronal Plasticity biology Laminectomy General Medicine Anatomy Recovery of Function medicine.disease Spinal cord Rats 030104 developmental biology medicine.anatomical_structure Synaptophysin biology.protein Female medicine.symptom Filopodia 030217 neurology & neurosurgery |
| Zdroj: | Archives of medical research. 48(7) |
| ISSN: | 1873-5487 |
| Popis: | Background Spinal cord injury (SCI) is highly incapacitating, and the neurobiological factors involved in an eventual functional recovery remain uncertain. Plastic changes to dendritic spines are closely related with the functional modifications of behavior. Aim of the Study To explore the plastic response of dendritic spines in motoneurons after SCI. Methods Female rats were assigned to either of three groups: Intact (no manipulations), Sham (T9 laminectomy), and SCI (T9 laminectomy and spinal cord contusion). Results Motor function according to a BBBscale was progressively recovered from 2 week through 8 week postinjury, reaching a plateau through week 16. Dendritic spine density was greater in SCI vs. control groups, rostral as well as caudal to the lesion, at 8 and 16 weeks postinjury. Thin and stubby/wide spines were more abundant at both locations and time points, whereas mushroom spines predominated at 2 and 4 months in rostral to the lesion. Filopodia and atypical structures resembling dendritic spines were observed. Synaptophysin expression was lower in SCI at the caudal portion at 8 weeks, and was higher at week 16. Conclusion Spinogenesis in spinal motoneurons may be a crucial plastic response to favor spontaneous recovery after SCI. |
| Databáze: | OpenAIRE |
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