Flow Sensing of Single Cell by Graphene Transistor in a Microfluidic Channel

Autor:	Chwee Teck Lim, Yu Wang, Priscilla Kailian Ang, Kian Ping Loh, Manu Jaiswal, Han Wei Hou, Ang Li, John T. L. Thong
Rok vydání:	2011
Předmět:	Materials science Graphene Mechanical Engineering Microfluidics Transistor Charge density Conductance Transistor array Bioengineering Nanotechnology General Chemistry Dielectric Condensed Matter Physics law.invention law General Materials Science Field-effect transistor
Zdroj:	Nano Letters. 11:5240-5246
ISSN:	1530-6992 1530-6984
DOI:	10.1021/nl202579k
Popis:	The electronic properties of graphene are strongly influenced by electrostatic forces arising from long-range charge scatterers and by changes in the local dielectric environment. This makes graphene extremely sensitive to the surface charge density of cells interfacing with it. Here, we developed a graphene transistor array integrated with microfluidic flow cytometry for the "flow-catch-release" sensing of malaria-infected red blood cells at the single-cell level. Malaria-infected red blood cells induce highly sensitive capacitively coupled changes in the conductivity of graphene. Together with the characteristic conductance dwell times, specific microscopic information about the disease state can be obtained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f975f146ea02084b03b346677b1338a https://doi.org/10.1021/nl202579k Zobrazit plný text záznamu