Antibiotics in early life alter the murine colonic microbiome and adiposity
| Autor: | Isabel Teitler, Barbara A. Methé, Laura M. Cox, Ilseung Cho, Zhan Gao, Shingo Yamanishi, Jiri Zavadil, Kartik Raju, Huilin Li, Douglas Mahana, Kelvin Li, Martin J. Blaser, Alexander V. Alekseyenko |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Colon medicine.drug_class Antibiotics Gastric Inhibitory Polypeptide Weaning Biology Pharmacology Polymerase Chain Reaction Article Feces Mice Gastric inhibitory polypeptide Bone Density Internal medicine medicine Animals Microbiome Cecum Adiposity chemistry.chemical_classification Bone Development Multidisciplinary Body Weight Age Factors Fatty acid Lipid metabolism Metabolism Fatty Acids Volatile Lipid Metabolism Anti-Bacterial Agents Mice Inbred C57BL Cholesterol Endocrinology Liver chemistry Body Composition Metagenome Female Drug metabolism Hormone |
| Zdroj: | Nature. 488:621-626 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature11400 |
| Popis: | Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation. |
| Databáze: | OpenAIRE |
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