Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection
| Autor: | Atul K. Bhan, Andrew W. Tai, Carolina B. De Sa Borges, Ethan M. Weinberg, Run-Xuan Shao, Kyung Ah Kim, Wenyu Lin, Yoshitaka Kamegaya, Hui Zheng, Raymond T. Chung |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Genotype Biopsy Hepacivirus Hepatitis C virus Black People HIV Infections Suppressor of Cytokine Signaling Proteins medicine.disease_cause Antiviral Agents Article White People chemistry.chemical_compound Predictive Value of Tests medicine Humans Treatment Failure SOCS3 Hepatology biology Ribavirin Racial Groups digestive oral and skin physiology virus diseases Hepatitis C Hepatitis C Chronic Viral Load medicine.disease biology.organism_classification STAT1 Transcription Factor Treatment Outcome Liver chemistry Suppressor of Cytokine Signaling 3 Protein Immunology Female Viral disease Viral load |
| Zdroj: | Journal of Hepatology. 50:705-711 |
| ISSN: | 0168-8278 |
| Popis: | Background/Aims The response rates of HCV infection to interferon therapy vary depending on viral and host factors. We hypothesized that key regulators of the IFN signaling pathway are predictive of treatment outcome. Methods We measured the expression of signal transducer and activator of transcription 1 (STAT1) and suppressor of cytokine signaling 3 (SOCS3) in pretreatment liver biopsies. Staining quantitation was compared to treatment outcomes. Results Forty-nine patients with HCV and 25 patients with HCV/HIV infection treated with peginterferon/ribavirin were analyzed. Pretreatment hepatic SOCS3 expression was higher in non-responders than responders. Genotype 1 responders had similar levels of SOCS3 as genotype 2/3 responders. African Americans (AA) had higher hepatic SOCS3 than non-AA. Pretreatment hepatic SOCS3 was the most powerful independent predictor of sustained virologic response (SVR), even more so than genotype by logistic regression analysis. Failure to achieve SVR and AA race were independently associated with high hepatic SOCS3 levels. The hepatic expression of STAT-1 did not differ between responders and non-responders. Conclusions Our data indicate that hepatic SOCS3 is a stronger baseline predictor of antiviral response than viral genotype. Poor response to antiviral therapy in AA may be associated with higher hepatic SOCS3 expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect