Graft-versus-host Disease After Intestinal or Multivisceral Transplantation: A Scandinavian Single-center Experience
| Autor: | Jan-Erik Johansson, Julia Cromvik, G. Herlenius, Christine Wennerås, J. Varkey |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Graft vs Host Disease chemical and pharmacologic phenomena Malignancy Single Center Gastroenterology immune system diseases Risk Factors Internal medicine Biopsy Leukocytes Medicine Humans Transplantation Homologous Aged Retrospective Studies Sweden Transplantation Chemotherapy Transplantation Chimera medicine.diagnostic_test Passenger leukocyte business.industry Incidence Middle Aged medicine.disease Tissue Donors Surgery Intestines Viscera surgical procedures operative Graft-versus-host disease medicine.anatomical_structure Female Bone marrow business |
| Zdroj: | Transplantation proceedings. 48(1) |
| ISSN: | 1873-2623 |
| Popis: | Background Graft-versus-host disease (GVHD) that develops after intestinal or multivisceral transplantation is difficult to diagnose and is associated with high morbidity and mortality. Material and Methods The objectives of this study were to investigate the incidence, clinical picture, risk factors, and outcome of GVHD in a Scandinavian cohort of patients who underwent intestinal or multivisceral transplantation during a period of 16 years (1998–2014). All transplanted patients (n = 26) were retrospectively analyzed with respect to donor- and recipient-derived risk factors. The diagnosis of GVHD was based on clinical signs, chimerism analyses of leukocytes, and histopathologic findings in biopsy specimens. Results Five of 26 patients (19%) were diagnosed with GVHD, of which three had skin GVHD, one had skin and bone marrow GVHD, and one had passenger leukocyte syndrome. Only multivisceral-transplanted patients developed GVHD. Risk factors for development of GVHD were an underlying tumor diagnosis and neoadjuvant chemo- or brachytherapy administered before intestinal transplantation. All patients were given high-dose corticosteroids as first line treatment for their GVHD, and all survived their episodes of GVHD. Conclusions The risk of GVHD appears to be increased in recipients of multivisceral transplantations who received chemotherapy due to an underlying malignancy. The reasons may be the large amount of lymphoid tissue in these types of grafts, and the cytotoxic effects of the malignancy and chemotherapy on healthy recipient tissues. These patients should be monitored closely for the development of GVHD. |
| Databáze: | OpenAIRE |
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