Transcranial pulsed ultrasound stimulates intact brain circuits
| Autor: | William J. Tyler, Monica L. Tauchmann, Nathan Baldwin, Joseph Georges, Anna Yoshihiro, Stephen I. Helms Tillery, Yusuf Tufail, Alexei Matyushov |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Neurons
business.industry Ultrasonography Doppler Transcranial General Neuroscience medicine.medical_treatment Neuroscience(all) Ultrasound Brain Stimulation Optogenetics Hippocampus Transcranial Doppler Transcranial magnetic stimulation Mice medicine.anatomical_structure Transcranial pulsed ultrasound medicine Premovement neuronal activity Animals Ultrasonics Nerve Net SYSNEURO business Neuroscience Motor cortex |
| Zdroj: | Neuron. 66(5) |
| ISSN: | 1097-4199 |
| Popis: | Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|