Functional abnormality in the sensorimotor system attributed to NRXN1 variants in boys with attention deficit hyperactivity disorder
| Autor: | Li An, Yufeng Wang, Qingjiu Cao, Li Yang, Yuanxin Zhong |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Mediation (statistics) Cerebellum Cognitive Neuroscience behavioral disciplines and activities Behavioral Neuroscience Cellular and Molecular Neuroscience Gyrus Cortex (anatomy) mental disorders Humans Medicine Attention deficit hyperactivity disorder Radiology Nuclear Medicine and imaging Association (psychology) Neural Cell Adhesion Molecules Neuroradiology Brain Mapping business.industry Calcium-Binding Proteins Neuropsychology Brain medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Neurology Attention Deficit Disorder with Hyperactivity Neurology (clinical) business Neuroscience |
| Zdroj: | Brain Imaging and Behavior. 16:967-976 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | Impaired sensorimotor circuits have been suggested in Attention-deficit/hyperactivity disorder (ADHD). NRXN1, highly expressed in cortex and cerebellum, was one of the candidate risk genes for ADHD, while its effects on sensorimotor circuits are unclear. In this content, we aimed to investigate the differential brain effects as functions of the cumulative genetic effects of NRXN1 variants in ADHD and healthy controls (HCs), identifying a potential pathway mapping from NRXN1, sensorimotor circuits, to ADHD. Magnetic resonance imaging, blood samples and clinical assessments were acquired from 53 male ADHD and 46 sex-matched HCs simultaneously. The effects of the cumulative genetic effects of NRXN1 variants valued by poly-variant risk score (PRS), on brain function was measured by resting-state functional connectivity (rs-FC) of cerebrocerebellar circuits. Mediation analyses were conducted to evaluate the association between NRXN1, functional abnormality, and ADHD diagnosis, as well as ADHD symptoms. The results were validated by bootstrapping and 10,000 times permutation tests. The rs-FC analyses demonstrated significant mediation models for ADHD diagnosis, and emphasized the involvement of cerebellum, middle cingulate gyrus and temporal gyrus, which are crucial parts of sensorimotor circuits. The current study suggested NRXN1 conferred risk for ADHD by regulating the function of sensorimotor circuits. |
| Databáze: | OpenAIRE |
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