Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function

Autor: Jordi Mayneris-Perxachs, María Arnoriaga-Rodríguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Maria Trelis, Aurelijus Burokas, Clàudia Coll, Cristina Zapata-Tona, Salvador Pedraza, Vicente Pérez-Brocal, Lluís Ramió, Wifredo Ricart, Andrés Moya, Mariona Jové, Joaquim Sol, Manuel Portero-Otin, Reinald Pamplona, Rafael Maldonado, José Manuel Fernández-Real
Rok vydání: 2021
Předmět:
Zdroj: ISME JOURNAL
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
The ISME Journal, London : Nature publishing group, 2022, vol. 16, iss. 9, p. 2181-2197
r-FISABIO. Repositorio Institucional de Producción Científica
Mayneris-Perxachs, Jordi Arnoriaga-Rodríguez, María Garre-Olmo, Josep Puig, Josep Ramos Blanes, Rafael Trelis Villanueva, María Burokas, Aurelijus Coll, Clàudia Zapata-Tona, Cristina Pedraza, Salvador Pérez-Brocal, Vicente Ramió, Lluís Ricart, Wifredo Moya Simarro, Andrés Jové, Mariona Sol, Joaquim Portero-Otin, Manuel Pamplona, Reinald Maldonado, Rafael Fernández-Real, José Manuel 2022 Presence of Blastocystis in the gut microbiota is associated with cognitive traits and decreased executive function Isme Journal 16 9 2181 2197
RODERIC. Repositorio Institucional de la Universitat de Valéncia
ISME Journal
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
ISSN: 1751-7370
2017-0734
1751-7362
Popis: Growing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in humans but its potential involvement in human pathophysiology has been poorly characterized. Here we describe how the presence of Blastocystis in the gut microbiome was associated with deficits in executive function and altered gut bacterial composition in a discovery (n = 114) and replication cohorts (n = 942). We also found that Blastocystis was linked to bacterial functions related to aromatic amino acids metabolism and folate-mediated pyrimidine and one-carbon metabolism. Blastocystis-associated shifts in bacterial functionality translated into the circulating metabolome. Finally, we evaluated the effects of microbiota transplantation. Donor's Blastocystis subtypes led to altered recipient's mice cognitive function and prefrontal cortex gene expression. In summary, Blastocystis warrant further consideration as a novel actor in the gut microbiome-brain axis. This study was partially funded by the Catalan Government (AGAUR, #SGR2017-0734, ICREA Academia Award 2021) to J.M.F.-R., Instituto de Salud Carlos III (Madrid, Spain) through the projects PI15/01934, PI18/01022 and PI21/01361 to JMF-R, the project PI20/01090 (Co-funded by European Regional Development Fund “A way to make Europe”) to JM-P, and the project PI20/0155 to MP-O; the grants SAF2015-65878-R from Ministry of Economy and Competitiveness, Prometeo/2018/A/133 from Generalitat Valenciana, Spain and also by Fondo Europeo de Desarrollo Regional (FEDER) funds (“A way to build Europe”), European Commission (FP7), the Catalan Government (AGAUR, #SGR2017-669, ICREA Academia Award 2020 and Ministerio de Ciencia e Innovación PID2020- 120029GB-I00/MICIN/AEI/10.13039/501100011033, and RD21/0009/0019, European Commission-DG Research” (PainFact, H2020-SC1-2019-2-RTD-848099, QSPain Relief, H2020-SC1-2019-2-RTD-848068 to R.M.), the Spanish Instituto de Salud Carlos III (RTA, #RD16/0017/0020) and the European Regional Development Fund (project No. 01.2.2-LMT-K-718-02-0014) under grant agreement with the Research Council of Lithuania (LMTLT). We also acknowledge funding from the Spanish Ministry of Science, Innovation and Universities (RTI2018-099200-B-I00), and the Generalitat of Catalonia (Agency for Management of University and Research Grants (2017SGR696) and Department of Health (SLT002/16/00250)) to RP; María Arnoriaga-Rodríguez is funded by Instituto de Salud Carlos III, Río Hortega (CM19/00190). JM-P is funded by Instituto de Salud Carlos III through the Miguel Servet Program project CP18/00009 (Co-funded by the European Social Fund “Investing in your future”). MJ is a “Serra-Hunter” fellow.
Databáze: OpenAIRE
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