Oral human papillomavirus infection in women with cervical HPV infection: new data from an Italian cohort and a metanalysis of the literature
| Autor: | Lucia Giovannelli, Domenica Matranga, Maria Pia Caleca, Antonio Perino, Carmelina Bellavia, Nicoletta Termine, Giuseppina Campisi |
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| Přispěvatelé: | Termine, N, Giovannelli, L, Matranga, D, Caleca, MP, Bellavia, C, Perino, A, Campisi G |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Sexually transmitted infection Metanalysis Hpv detection Uterine Cervical Diseases HIV/HPV infection Settore MED/28 - Malattie Odontostomatologiche Internal medicine medicine Humans Sex organ Oral hpv Human papillomavirus Gynecology business.industry Papillomavirus Infections HPV infection virus diseases medicine.disease Head and neck squamous-cell carcinoma Cross-Sectional Studies Oncology Italy Cohort Female Cervical HPV infection Hiv status Oral Surgery Oral HPV infection business Mouth Diseases |
| Zdroj: | Oral oncology. 47(4) |
| ISSN: | 1879-0593 |
| Popis: | Summary A key issue in oral HPV infection is whether it can be associated with a genital HPV infection, or whether it can be considered as an independent event. This analysis evaluated the frequency and type-concordance of oral HPV infection in women with cervical HPV infection by means of: (i) a cross-sectional study on a sample (n = 98) of Italian women; and (ii) a literature-based metanalysis, including the experimental study the subject of this Paper and nine other published studies (n = 1017), which also examined the influence of oral sampling procedure (oral brushing vs oral rinse) and HIV status on oral HPV detection. The prevalence of oral HPV infection in the Italian study was 14.3% (95% CI: 7.4–21.2); the prevalence of type-concordance was 21.4% (95% CI: 0.0–43.6) and it was only marginally significant (P = 0.05). The prevalence of oral HPV infection in the metanalysis was estimated as 18.1% (95% CI: 10.3–25.9); the prevalence of type-concordance was 27.0% (95% CI: 12.3–41.7), and it was statistically significant (P = 0.002). The metanalysis also showed that the oral sampling procedure was not a determinant of HPV detection; however, HIV status increased the likelihood of oral HPV infection (HIV-positive vs negative: 27.2%; 95% CI: 22.1–32.2 vs 15.5%; 95% CI: 6.9–24.2) and type-concordance (HIV-positive vs negative: 46.8%; 95% CI: 34.7–58.9 vs 15.6%; 95% CI: 0.8–30.4). Oral HPV infection and type-concordance in women with cervical HPV infection are more prevalent than could be expected by chance; this finding is consistent with the notion of a degree of dependence of the oral site on the cervical site. Furthermore, oral HPV prevalence and type-concordance are influenced by immunity. |
| Databáze: | OpenAIRE |
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