Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
| Autor: | Yunpeng Zhao, Dan Luo, Tianyi Liu, Xing Xiao, Haodong Hou, Kai Bian, Mingzhi Yu, Hanwen Zhang, Cheng Qiu, Yichao Han |
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| Rok vydání: | 2021 |
| Předmět: |
Cell type
Inflammation Review Pentraxin 3 Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Immunity Synovitis medicine Animals Humans Rheumatoid arthritis Pentraxin-3 business.industry General Medicine PTX3 medicine.disease Immunity Innate Disease Models Animal Serum Amyloid P-Component C-Reactive Protein TNF-α Immunology Disease Progression Autoimmune inflammatory disease 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.54787 |
| Popis: | Rheumatoid arthritis (RA) is a systemic chronic autoimmune inflammatory disease which is mainly characterized by synovitis and results in a severe burden for both the individual and society. To date, the underlying mechanisms of RA are still poorly understood. Pentraxin 3 (PTX3) is a typical long pentraxin protein which has been highly conserved during evolution. Meanwhile, functions as well as properties of PTX3 have been extensively studied. Several studies identified that PTX3 plays a predominate role in infection, inflammation, immunity and tumor. Interestingly, PTX3 has also been verified to be closely associated with development of RA. We therefore accomplished an elaboration of the relationships between PTX3 and RA. Herein, we mainly focus on the associated cell types and cognate cytokines involved in RA, in combination with PTX3. This review infers the insight into the interaction of PTX3 in RA and aims to provide novel clues for potential therapeutic target of RA in clinic. |
| Databáze: | OpenAIRE |
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