Inactivated suckling mouse brain rabies vaccine provides short-term immunity in capuchin monkeys (Cebus apella)
| Autor: | Cleide Aschenbrenner Consales, Sandra Helena Ramiro Corrêa, Marcelo Alcindo de Barros Vaz Guimarães, E. C Passos, José D. L. Fedullo, M. A Gonçalves, Pedro Manuel Leal Germano, Maria L. Carrieri |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Time Factors Rabies Brain tissue Antibodies Viral Injections Intramuscular Mice Rabies vaccine Immune system Immunity medicine Animals Cebus Immunization Schedule General Veterinary biology Monkey Diseases Brain General Medicine medicine.disease Virology Animals Suckling Vaccination Titer Rabies Vaccines Vaccines Inactivated Rabies virus biology.protein Animal Science and Zoology Animals Zoo Female Antibody medicine.drug |
| Zdroj: | Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 32(1) |
| ISSN: | 1042-7260 |
| Popis: | Eight capuchin monkeys (Cebus apella) were vaccinated against rabies with an inactivated suckling mouse brain vaccine (SMBV). Three 1-ml doses of 2% brain tissue suspension were given by i.m. injection at 0, 30, and 60 days. Blood samples were collected at 0, 30, 60, 90, 150, 210, 240, 300, and 365 days and were tested by simplified fluorescence inhibition to titer-neutralizing antibodies. All of the animals developed neutralizing antibodies with titers >0.5 IU/ml after vaccination, but the immune response persisted for only 122.3 ± 32.6 days. The SMBV was able to induce immune response in the capuchin monkeys, but protection was short-lived. |
| Databáze: | OpenAIRE |
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