Taxifolin and Fucoidin Abolish the Irradiation-Induced Increase in the Production of Reactive Oxygen Species in Rat Aorta
| Autor: | T. V. Arutyunyan, Vera V. Shaposhnikova, L. N. Kublik, A. F. Korystova, M. Kh. Levitman, Yu. N. Korystov |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Endothelium Pharmacology Polysaccharide General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polysaccharides medicine.artery Cell Adhesion Leukocytes medicine Animals Taxifolin Irradiation Rats Wistar Cell adhesion Aorta chemistry.chemical_classification Reactive oxygen species X-Rays General Medicine Rats 030104 developmental biology medicine.anatomical_structure chemistry Anesthesia Quercetin Reactive Oxygen Species 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 160:635-638 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-016-3236-2 |
| Popis: | We studied changes in ROS content in the aorta of Wistar rats at early terms after irradiation in doses equal to single fraction used in tumor radiotherapy and the effects of taxifolin and fucoidin, blockers of leukocyte adhesion to endothelium, on ROS content. Male rats were exposed to X-rays (200 kW) in doses of 1-7.5 Gy. ROS production in aorta segments was measured in 1-48 h after irradiation by dichlorodihydrofluorescein oxidation. The content of ROS in the aorta of rats exposed to radiation in doses of 1-2.5 Gy increased in 1-24 h after irradiation, the peak ROS content was found in 2 h after irradiation. Taxifolin (100 μg/kg dihydroquercetin once a day with drinking water) and fucoidin (10 mg/kg, i.v.) abolished ROS accumulation. The content of ROS in rat aorta increased in 1-24 h after irradiation in doses used for tumor radiotherapy and this increase can be determined by leukocyte adhesion to the endothelium. |
| Databáze: | OpenAIRE |
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