Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir
| Autor: | Kaline Cavalheiro, Fernanda Carlos Rodrigues de Almeida, Regina Célia de Menezes Succi, Maria Regina Alves Cardoso, Fabiana Bononi, Suenia Vasconcelos Beltrão, Aída de Fátima Thomé Barbosa Gouvêa, Daniela Souza Araújo de Angelis, Daisy Maria Machado, Kelly Simone Almeida Cunegundes |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP), São Paulo University Faculty of Public Health, Universidade de São Paulo (USP) |
| Rok vydání: | 2007 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty HAART Population lcsh:QR1-502 Lopinavir/ritonavir Pyrimidinones Gastroenterology lcsh:Microbiology Lopinavir lcsh:Infectious and parasitic diseases Immune system children Antiretroviral Therapy Highly Active Internal medicine medicine Humans lcsh:RC109-216 Protease inhibitor (pharmacology) Longitudinal Studies Child education Acquired Immunodeficiency Syndrome education.field_of_study Ritonavir business.industry HIV lopinavir/ritonavir HIV Protease Inhibitors Viral Load Antiretroviral therapy CD4 Lymphocyte Count lopinavir Regimen Treatment Outcome Infectious Diseases Child Preschool Immunology RNA Viral business Viral load Follow-Up Studies medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Volume: 11, Issue: 1, Pages: 16-19, Published: FEB 2007 Brazilian Journal of Infectious Diseases v.11 n.1 2007 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 11, Iss 1, Pp 16-19 Repositório Institucional da UNIFESP Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| ISSN: | 1413-8670 |
| DOI: | 10.1590/s1413-86702007000100006 |
| Popis: | This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to > 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was assessed. Sixteen (55.2%) and 19 (65.5%) of 29 patients exhibited good virological and immunological responses, respectively. Baseline CD4+ values (>500) predicted both virological and immunological responses (p |
| Databáze: | OpenAIRE |
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