Interaction of tobacco smoke exposure and ovalbumin-sensitization promotes goblet cell and submucosal gland metaplasia in guinea pigs
| Autor: | Suresh Pavuluri, Veronica Hanus, Dale R. Bergren |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Time Factors Ovalbumin Physiology Guinea Pigs Aluminum Hydroxide Exocrine Glands Airway resistance Administration Inhalation Leukocytes Respiratory Hypersensitivity medicine Animals Sensitization Submucosal glands Metaplasia Goblet cell Lung Inhalation biology business.industry Airway Resistance General Neuroscience Smoking respiratory system respiratory tract diseases medicine.anatomical_structure Immunology biology.protein Airway Remodeling Goblet Cells Airway business |
| Zdroj: | Respiratory Physiology & Neurobiology. 189:639-645 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2013.07.019 |
| Popis: | Exposure to irritants such as tobacco smoke (TS) causes acute airway inflammation. Chronic exposure may cause airway remodeling contributing to enhanced airway resistance. We hypothesize that combining airway sensitization and inhalation of irritants enhances the number of mucous producing cells beyond either agent alone. Guinea pigs were antigen sensitized or treated with its vehicle. These two groups were further divided into daily exposure to TS or air. After 3 months airway reactivity to ovalbumin (OA) was determined, airway and blood samples were examined and lung substance P quantified. Combining sensitization and TS exposure increased airway reactivity to OA, goblet cell and submucosal gland populations. Airway eosinophilia was greatest in the OA-sensitized group exposed to air rather than with its combination with TS exposure. Lung substance P levels were similarly elevated in both OA-sensitized groups. Airway irritant exposure in which airway sensitization exists enhances the potential of mucus production, airway resistance and mucus plugging of the airways through increasing the number of goblet cells and submucosal glands. |
| Databáze: | OpenAIRE |
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