Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide
| Autor: | Shuji Kaneko, Takayuki Nakagawa, Shohei Oyama, Koji Dogishi, Hisashi Shirakawa, Mizuki Kodera |
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| Rok vydání: | 2015 |
| Předmět: |
Long lasting
Time Factors Amitriptyline Chronic cystitis Pain Motor Activity chemistry.chemical_compound Cystitis medicine Animals Oxybutynin Hydrogen peroxide Pharmacology Behavior Animal Morphine business.industry lcsh:RM1-950 Painful bladder syndrome Syndrome Chronic Cystitis Analgesics Non-Narcotic Analgesics Opioid Disease Models Animal lcsh:Therapeutics. Pharmacology Administration Intravesical medicine.anatomical_structure chemistry Anesthesia Chronic Disease Molecular Medicine Abdomen Licking business medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 129, Iss 4, Pp 244-246 (2015) |
| ISSN: | 1347-8613 |
| DOI: | 10.1016/j.jphs.2015.11.003 |
| Popis: | We previously established a long-lasting cystitis model by an intravesical injection of hydrogen peroxide (H2O2) into mice. In this study, we assessed the pain-related behaviors in the cystitis model. An intravesical injection of 1.5% H2O2 transiently decreased spontaneous locomotor activity at 3 h after injection, indicative of acute spontaneous pain. In contrast, licking response to a bladder distention was slowly observed as licks to the lower abdomen at 7 and 14 days after injection, which was attenuated by amitriptyline and morphine, but not by oxybutynin. These results suggest that H2O2-induced chronic cystitis model shows delayed and long-lasting painful pathological condition. |
| Databáze: | OpenAIRE |
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