Toxicity potential of oral lidocaine in a patient receiving mexiletine
| Autor: | Kenneth A. Ballew, Shane D. Scott, Douglas R. Geraets |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cardiomyopathy
Dilated Central Nervous System Lidocaine medicine.drug_class Cardiomyopathy Administration Oral Mexiletine Body weight 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Medicine Humans Pharmacology (medical) In patient 030212 general & internal medicine business.industry Local anesthetic Middle Aged medicine.disease Anesthesia Toxicity Female business Medline database medicine.drug |
| Zdroj: | The Annals of pharmacotherapy. 26(11) |
| ISSN: | 1060-0280 |
| Popis: | OBJECTIVE: To report a case of toxicity from orally administered lidocaine in a patient with cardiomyopathy receiving concurrent mexiletine therapy. DATA SOURCES: Case reports, review articles, and studies identified by search of the MEDLINE database and Current Contents. STUDY SELECTION: All reports of toxicity from orally administered lidocaine were reviewed. DATA SYNTHESIS: Lidocaine, a local anesthetic, is widely used to treat cardiac arrhythmias. Toxicity with the parenteral form occurs frequently. In contrast, there are few reports of toxicity with oral lidocaine, most of them occurring in children receiving large doses relative to body weight. We report a case of intoxication in an adult with severe cardiomyopathy and concurrent mexiletine therapy who received only two doses of oral lidocaine. CONCLUSIONS: Although it is rarely reported in adults, clinicians must be alert to the possibility of toxicity from orally administered lidocaine. This is most likely to occur in patients with conditions known to reduce lidocaine clearance, when higher-than-usual doses are administered, or when concurrent therapy with oral lidocaine analogs may be present. |
| Databáze: | OpenAIRE |
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