Viral causes of unexplained anterior uveitis in Thailand
| Autor: | Aniki Rothova, Paradee Kunavisarut, Natedao Kongyai, Pranee Leechanachai, Wasna Sirirungsi, Napaporn Tananuvat, Kessara Pathanapitoon, J D F de Groot-Mijnes |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Herpesvirus 3 Human Adolescent viruses Cytomegalovirus Eye Infections Viral medicine.disease_cause Real-Time Polymerase Chain Reaction Herpes Zoster Virus Aqueous Humor Young Adult medicine Humans Simplexvirus Child Endotheliitis Aged business.industry Varicella zoster virus virus diseases Infant Rubella virus Herpes Simplex Middle Aged medicine.disease Thailand Virology Uveitis Anterior Ophthalmology Herpes simplex virus Intraocular fluid Child Preschool Immunology Cytomegalovirus Infections DNA Viral Clinical Study Female business Uveitis |
| Zdroj: | Eye (London, England). 26(4) |
| ISSN: | 1476-5454 |
| Popis: | To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU). Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by real-time polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann–Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner–Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS. Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus. |
| Databáze: | OpenAIRE |
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