Effects of Toborinone (OPC-18790), a New Positive Inotropic Agent, on Action Potential in Guinea Pig Sinoatrial Node: Compared with Milrinone and E-4031
| Autor: | Hiromichi Takase, Kensuke Orito, Toyoki Mori, Hiroyuki Fujiki |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Cardiotonic Agents Phosphodiesterase Inhibitors Pyridines Pyridones Guinea Pigs Diastole Action Potentials Quinolones Toborinone Guinea pig chemistry.chemical_compound Piperidines Internal medicine medicine Animals Sinoatrial Node Pharmacology Membrane potential Analysis of Variance Sinoatrial node Phosphodiesterase Electrophysiology Endocrinology medicine.anatomical_structure chemistry E-4031 Milrinone Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 72:79-82 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.72.79 |
| Popis: | The effects of toborinone ([(±)-6-[3-(3,4-dimethoxybenzylamino)-2-tiydroxypropoxy]-2(1H)-quinolinone], OPC-18790), milrinone and E-4031 (1-(2-(6-methyl-2-pyridil)-1-ethyl)-4-(4-methanesulfonyl-amino-l-benzoyl)piperidine dihydrochloride) on membrane potential were examined in isolated guinea pig sinoatrial node preparations. Toborinone, a new positive inotropic agent, prolonged cycle length (CL), depolarized maximum diastolic potential (MDP) and decreased maximum upstroke velocity (V-,) and action potential amplitude (APA). On the other hand, milrinone, a peak III phosphodiesterase (PDE III) inhibitor, increased Vmax and APA and shortened CL and action potential duration. E-4031, an IK blocker, prolonged CL, depolarized MDP and decreased Vmax and APA. These results suggest that toborinone modulates the action potential like an IK blocker rather than a PDE III inhibitor in a sinoatrial node. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|