Determination of multi‐class antibiotic residues in compost by microwave‐enhanced accelerated solvent extraction and ultra performance convergence chromatography with tandem mass spectrometry

Autor:	Yu-peng Ren, Yang Zhou, Jian Zhang, Xue-Feng Lu
Rok vydání:	2019
Předmět:	Liquid-Liquid Extraction Filtration and Separation 010501 environmental sciences engineering.material Tandem mass spectrometry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Tandem Mass Spectrometry Impurity Microwaves Chromatography High Pressure Liquid 0105 earth and related environmental sciences Chromatography Compost Methanol 010401 analytical chemistry Extraction (chemistry) Carbon Dioxide Drug Residues Supercritical fluid Anti-Bacterial Agents 0104 chemical sciences chemistry Carbon dioxide Solvents Supercritical fluid chromatography engineering
Zdroj:	Journal of Separation Science. 42:1281-1288
ISSN:	1615-9314 1615-9306
DOI:	10.1002/jssc.201801032
Popis:	This work reports the development and application of a multi-class compound analysis method for the determination of 20 antibiotic residues in compost. Samples were processed by microwave-enhanced accelerated solvent extraction at 120°C for 7.5 min. Salting-out homogeneous liquid-liquid extraction was used to remove water and water-soluble impurities from the extract before ultra performance convergence chromatography with tandem mass spectrometry analysis. By using the supercritical fluid (carbon dioxide) and organic solvent (methanol) as the mobile phase, the 20 antibiotics and the internal standard were well separated in 8.2 min without obvious matrix effect. Method validation was performed and good trueness (relative error in the range of ±5.0%) and precision (inter- and intraday relative standard deviations < 10.8%) were obtained. Method detection and quantitation limits were 0.8-1.9 and 2.7-7.1 ng/g, respectively. Recoveries were assessed at three concentration levels (10, 60, and 400 ng/g) and acceptable mean values (70.4-111.9%) were found. This method has also been used to analyze real samples, and the average concentrations of antibiotics (excepting the concentrations < method quantitation limits) were determined up to 123.6 ng/g. The results showed the method could be helpful for the analysis of multi-class antibiotics in environmental samples.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7b823c3c5fafd8bd51c32918e72d0e https://doi.org/10.1002/jssc.201801032 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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