Polyhistidine-Based Metal Coordination Hydrogels with Physiologically Relevant pH Responsiveness and Enhanced Stability through a Novel Synthesis
| Autor: | Haiyang Yang, Quan Tang, Kang Peng, Qiang Zhou, Xingyuan Zhang, Dinglei Zhao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
02 engineering and technology Indigo Carmine 010402 general chemistry 01 natural sciences Buffer (optical fiber) Polyethylene Glycols Metal chemistry.chemical_compound PEG ratio Materials Chemistry Histidine Edetic Acid Drug Carriers Chemistry Organic Chemistry Phosphate buffered saline Hydrogels Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Combinatorial chemistry 0104 chemical sciences Metals visual_art Self-healing Self-healing hydrogels visual_art.visual_art_medium Drug release 0210 nano-technology Ethylene glycol |
| Zdroj: | Macromolecular Rapid Communications. 39:1800109 |
| ISSN: | 1022-1336 |
| Popis: | Utilizing the abnormal physiological conditions of disease tissues can result in a site-specific functionality with high control and efficiency of stimuli-responsive hydrogels. Here, a physiologically relevant pH-responsive and self-healing hydrogel is reported based on coordination between Ni2+ and four-arm poly(ethylene glycol)-b-polyhistidine (4PEG-PHis) that is synthesized by a novel and facile PHis preparation method using amino-terminalized four-arm PEG as the macroinitiator. Reversible PHisNi coordination bonds endow the hydrogel with multistimuli-triggered sol-gel transition (physiologically relevant pH, EDTA) and self-healing properties. It is also demonstrated that 4PEG-PHis could be used as an injectable hydrogel in phosphate buffer (pH 7.4), and excellent stability in neutral buffer via multivalent coordination is shown, thus indicating its potential applications in controlled drug release systems. |
| Databáze: | OpenAIRE |
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