The Pro12Ala polymorphism of the PPAR gamma 2 gene is associated with hepatic glucose uptake during hyperinsulinemia in subjects with type 2 diabetes mellitus
| Autor: | Patricia Iozzo, Kirsti Hällsten, Juhani Knuuti, Ronald Borra, Jukka Kemppainen, Teemu Takala, Jussi Pihlajamäki, Markku Laakso, Pirjo Nuutila, Miikka-Juhani Honka, Kirsi A. Virtanen, Markku Vänttinen, Antti Viljanen, Riikka Lautamäki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty LIVER Proline endocrine system diseases Endocrinology Diabetes and Metabolism Glucose uptake Adipose tissue Type 2 diabetes Biology Endocrinology POSITRON-EMISSION-TOMOGRAPHY Hyperinsulinism Diabetes mellitus Internal medicine medicine Hyperinsulinemia Humans Alanine Polymorphism Genetic INSULIN SENSITIVITY Skeletal muscle Type 2 Diabetes Mellitus nutritional and metabolic diseases SUBSTITUTION MUSCLE medicine.disease PPAR gamma ROSIGLITAZONE medicine.anatomical_structure ADIPOSE-TISSUE Diabetes Mellitus Type 2 OBESITY Female PPAR-GAMMA Rosiglitazone RESISTANCE medicine.drug |
| Zdroj: | METABOLISM-CLINICAL AND EXPERIMENTAL, 58(4), 541-546. W B SAUNDERS CO-ELSEVIER INC |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/j.metabol.2008.11.015 |
| Popis: | The Ala12 allele of the peroxisome proliferator-activated receptor gamma gene (PPARG2) has been associated with reduced risk of type 2 diabetes mellitus (T2DM) and increased whole-body and skeletal muscle insulin sensitivity in nondiabetic subjects. The effect of the Pro12Ala polymorphism on tissue specific insulin sensitivity in subjects with T2DM has not been previously investigated. We studied the effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, and subcutaneous adipose tissue glucose uptake (GU) in T2DM subjects, and the rates of hepatic GU in nondiabetic and T2DM subjects during hyperinsulinemia. Our study included 105 T2DM subjects whose whole-body, skeletal muscle, subcutaneous adipose tissue, and hepatic GUs were measured using F-18-fluorodeoxyglucose and positron emission tomography during the hyperinsulinemic euglycemic clamp. Hepatic GU was also measured in 68 nondiabetic subjects. In obese (body mass index >= 27 kg/m(2)) subjects with T2DM, the rate of hepatic GU was 28% lower in subjects with the Pro12Pro genotype than in carriers of the Ala12 allele (P = .001); and a similar trend was observed in nondiabetic obese subjects (P = .137). No effect of the Pro12Ala polymorphism on the rates of whole-body, skeletal muscle, or subcutaneous adipose tissue GU was observed in T2DM subjects. We conclude that the Ala12 allele of PPARG2 is associated with higher hepatic GU in obese subjects with T2DM. (C) 2009 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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