Characterization of Soy Polysaccharide and Its In Vitro and In Vivo Evaluation for Application in Colon Drug Delivery
| Autor: | P. S. Soni, B. M. Ursekar, Mangal S. Nagarsenker, Abhijit A. Date |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Colon Drug Evaluation Preclinical Pharmaceutical Science Capsules Aquatic Science Polysaccharide Young Adult chemistry.chemical_compound Drug Delivery Systems Polysaccharides Oral administration In vivo Lactobacillus Drug Discovery Humans Pectinase Cellulose Ecology Evolution Behavior and Systematics chemistry.chemical_classification Chromatography Ecology biology Chemistry General Medicine Permeation biology.organism_classification Drug delivery Soybean Proteins Agronomy and Crop Science Research Article |
| Zdroj: | AAPS PharmSciTech. 13:934-943 |
| ISSN: | 1530-9932 |
| DOI: | 10.1208/s12249-012-9810-7 |
| Popis: | The objective of the present investigation was to establish potential of commercially available soy polysaccharide (Emcosoy®) for colon drug delivery. The soy polysaccharide-ethyl cellulose films were fabricated and characterized. The effect of the pectinase enzyme on the tensile strength and surface morphology of the film was evaluated. The permeation of chlorpheniramine maleate (CPM), a model hydrophilic drug from pectinase enzyme treated and untreated films was measured in pH 7.4 buffer. The soy polysaccharide-ethyl cellulose films were also incubated with Lactobacillus sp. culture for a specific duration, and effect on the CPM permeation was evaluated. The CPM capsules were coated with the soy polysaccharide-ethyl cellulose mixture, and Eudragit S100 was applied as a secondary coat. The coated CPM capsules were radiolabelled, and their in vivo transit was evaluated in human volunteers on oral administration. The pectinase enzyme had a significant influence on the tensile strength and surface morphology of the soy polysaccharide-ethyl cellulose films. The permeability of pectinase enzyme-treated and Lactobacillus sp.-treated films was significantly higher than that of untreated films. The CPM capsules were coated with the soy polysaccharide-ethyl cellulose mixture and Eudragit S100 and were successfully radiolabelled by a simple method. Gamma scintigraphic studies in human volunteers showed that the radiolabelled capsules maintained integrity for at least 9 h after oral administration. Thus, the soy polysaccharide has a potential in colon drug delivery. |
| Databáze: | OpenAIRE |
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