Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis

Autor:	Ye Lin, Uma Nayak, Jhansi L. Leslie, Matthew L. Jenior, Beth D. Kirkpatrick, James A Platts-Mills, Benjamin Lee, Rashidul Haque, Lauren K. Yum, Erin Weddle, Jennie Z. Ma, William A. Petri, Hervé Agaisse
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Microbiology (medical) Shigellosis Glycan 030231 tropical medicine shigellosis Blood group antigens 03 medical and health sciences 0302 clinical medicine Shigella flexneri Lewis Blood Group Antigens Antigen Shigella Infections Medicine Humans Online Only Articles Fucosylation Dysentery Bacillary blood-group antigens biology business.industry Infant biology.organism_classification medicine.disease In vitro 030104 developmental biology Infectious Diseases AcademicSubjects/MED00290 Immunology biology.protein Lewis antigens Brief Reports business
Zdroj:	Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
ISSN:	1537-6591 1058-4838
Popis:	In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in susceptibility to shigellosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f786e976b506a461605c285ec42a000 http://europepmc.org/articles/PMC8315233 Zobrazit plný text záznamu