Significance of pregnancy test false negative results due to elevated levels of β-core fragment hCG

Autor:	Saji Eapen, Graham Warren, Peter K. Smith, Sarah Johnson, Michael Zinaman
Rok vydání:	2017
Předmět:	Pregnancy test endocrine system medicine.medical_specialty Pregnancy Tests Chorionic gonadotrophin Point-of-Care Systems Clinical Biochemistry Immunology 030204 cardiovascular system & hematology Chorionic Gonadotropin 01 natural sciences Andrology 03 medical and health sciences 0302 clinical medicine Core fragment Pregnancy Internal medicine Humans Immunology and Allergy Medicine False Negative Reactions reproductive and urinary physiology urogenital system business.industry 010401 analytical chemistry medicine.disease 0104 chemical sciences Medical Laboratory Technology Endocrinology Female Early morning urine business hormones hormone substitutes and hormone antagonists
Zdroj:	Journal of Immunoassay and Immunochemistry. 38:449-455
ISSN:	1532-4230 1532-1819
Popis:	Very high levels of β-core fragment human chorionic gonadotrophin (βcf-hCG) are reported to potentially cause false negative results in point-of-care (POC)/over-the-counter (OTC) pregnancy tests. To investigate this further, women's daily early morning urine samples, collected prior to conception and during pregnancy, were analysed for intact, free β-, and βcf-hCG. The proportion of βcf-hCG was found to be related to that of hCG produced and in circulation. Therefore, best practice for accuracy testing of POC/OTC pregnancy tests would be to test devices against clinical samples containing high levels of βcf-hCG as well as standards spiked with biologically relevant ratios.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f722ce3a6412d446672cbf8649f3c93 https://doi.org/10.1080/15321819.2017.1329152 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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