Maternal viral mimetic administration at the beginning of fetal hypothalamic nuclei development accelerates puberty in female rat offspring
| Autor: | Pınar Çakan, Azibe Yildiz, Tuba Ozgocer, Nigar Vardi, Sedat Yildiz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Critical time Time Factors Physiology Offspring Hypothalamus Mothers Estrous Cycle Biology Viral infection Fetal Development 03 medical and health sciences 0302 clinical medicine Biomimetic Materials Pregnancy Physiology (medical) Internal medicine medicine Animals Pharmacology Fetus Puberty General Medicine Rats 030104 developmental biology Endocrinology Animals Newborn Maternal Exposure Viruses Female 030217 neurology & neurosurgery |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 96:506-514 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2016-0535 |
| Popis: | This study aimed to investigate the effects of maternal viral infection during a critical time window of fetal hypothalamic development on timing of puberty in the female offspring. For that purpose, a viral mimetic (i.e., synthetic double-strand RNA, namely, polyinosinic–polycytidylic acid, poly (I:C)) or saline was injected (i.p.) to the pregnant rats during the beginning (day 12 of pregnancy, n = 5 for each group) or at the end of this time window (day 14 of pregnancy, n = 5 for each group). Four study groups were formed from the female pups (n = 9–10 pups/group). Following weaning of pups, vaginal opening and vaginal smearing was studied daily until 2 sequential estrous cycles were observed. During the second diestrus phase, blood samples were taken for progesterone, leptin, corticosterone, follicle-stimulating hormone, and luteinizing hormone. Maternal poly (I:C) injection on day 12 of pregnancy increased body mass and reduced the time to puberty in the female offspring. Neither poly (I:C) nor timing of injection affected other parameters studied (p > 0.05). It has been shown for the first time that maternal viral infection during the beginning of fetal hypothalamic development might hasten puberty by increasing body mass in rat offspring. |
| Databáze: | OpenAIRE |
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