KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603
| Autor: | Shigehiro Takase, Masami Ezaki, Koji Yoshikawa, Michizane Hashimoto, Hirohito Kai, Kumiko Nitta, Akihiko Fujie, Ikuko Nakamura, Hideyuki Muramatsu, Masato Watanabe, Midori Yamashita, Noriaki Inamura |
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| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Rhizopus oryzae Microbial Sensitivity Tests Trichosporon asahii Microbiology Aspergillus fumigatus Pseudallescheria Trichosporon Drug Resistance Fungal Depsipeptides RNA Ribosomal 16S Drug Discovery Chromatography High Pressure Liquid Pharmacology Cryptococcus neoformans biology Sequence Analysis RNA Chemistry Antifungal antibiotic food and beverages biology.organism_classification 16S ribosomal RNA Pseudallescheria boydii RNA Bacterial Freeze Drying Fermentation Solvents Paenibacillus Rhizopus |
| Zdroj: | The Journal of Antibiotics. 66:465-471 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2013.63 |
| Popis: | The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C79H115N19O18. KB425796-A (1) showed antifungal activities against Aspergillus fumigatus and the micafungin-resistant infectious fungi Trichosporon asahii, Rhizopus oryzae, Pseudallescheria boydii and Cryptococcus neoformans. |
| Databáze: | OpenAIRE |
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