Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience
| Autor: | Tracy L. Bale, Ali B. Rodgers |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Epigenomics
Hypothalamo-Hypophyseal System Offspring Pituitary-Adrenal System Article Stress Disorders Post-Traumatic Transgenerational epigenetics Pregnancy medicine Animals Humans Epigenetics Biological Psychiatry Genetics biology Posttraumatic stress Disease Models Animal medicine.anatomical_structure Histone Germ Cells Prenatal Exposure Delayed Effects DNA methylation biology.protein Female Parental stress Psychology Germ cell |
| Zdroj: | Biological psychiatry. 78(5) |
| ISSN: | 1873-2402 |
| Popis: | Altered stress reactivity is a predominant feature of post-traumatic stress disorder (PTSD) and may reflect disease vulnerability, increasing the probability that an individual will develop PTSD following trauma exposure. Environmental factors, particularly prior stress history, contribute to the developmental programming of the hypothalamic-pituitary-adrenal (HPA) stress axis. Critically, the consequences of stress experiences are transgenerational, with parental stress exposure impacting stress reactivity and PTSD risk in subsequent generations. Potential molecular mechanisms underlying this transmission have been explored in rodent models specifically examining the paternal lineage, identifying epigenetic signatures in male germ cells as possible substrates of transgenerational programming. Here, we review the role of these germ cell epigenetic marks, including post-translational histone modifications, DNA methylation, and populations of small non-coding RNAs, in the development of offspring stress axis sensitivity and disease risk. |
| Databáze: | OpenAIRE |
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