Role of the PDR Gene Network in Yeast Susceptibility to the Antifungal Antibiotic Mucidin
| Autor: | Margita Obernauerova, Julius Subik, Dana Michalkova-Papajova |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Antifungal Agents
Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Mutant Microbiology Gene expression Transcriptional regulation Pharmacology (medical) Mechanisms of Action: Physiological Effects Gene Pharmacology Genetics biology Antifungal antibiotic Membrane Proteins Drug Resistance Microbial Strobilurins biology.organism_classification Yeast DNA-Binding Proteins Multiple drug resistance Infectious Diseases Fatty Acids Unsaturated Trans-Activators Methacrylates ATP-Binding Cassette Transporters Transcription Factors |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:418-420 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Yeast strains disrupted in the PDR1 , PDR3 , or PDR5 gene, but not in SNQ2 , exhibited higher sensitivity to mucidin (strobilurin A) than did the isogenic wild-type strains. Different gain-of-function mutations in the PDR1 and PDR3 genes rendered yeast mutants resistant to this antibiotic. Mucidin induced PDR5 expression, but the changes in the expression of SNQ2 were only barely detectable. The results indicate that PDR5 provides the link between transcriptional regulation by PDR1 and PDR3 and mucidin resistance of yeast. |
| Databáze: | OpenAIRE |
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