Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia
| Autor: | Wladimiro Jiménez, Virginia Nunes, Jordi Ribera, Manuel Morales-Ruiz, Ignacio de Miguel, Bernat Córdoba-Jover, Vanesa Sanz, Irene Portolés, Clara Vilches, Romain Quidant, Esther Prat |
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| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_treatment General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences Extracellular matrix Receptor Platelet-Derived Growth Factor beta Mice Fibrosis medicine Hepatic Stellate Cells Animals General Materials Science Hyperthermia biology Chemistry Growth factor General Engineering Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences medicine.anatomical_structure Liver Hepatocyte Cancer research biology.protein Hepatic stellate cell 0210 nano-technology Hepatic fibrosis Platelet-derived growth factor receptor |
| Zdroj: | ACS nano. 15(4) |
| ISSN: | 1936-086X |
| Popis: | Liver fibrosis is a major health problem with multiple associated complications, which, to date, has no effective treatment. Hepatic stellate cells are the main responsible cells for fibrosis formation; upon their activation, excess accumulation of extracellular matrix and collagen deposits occurs. The mitogen platelet-derived growth factor (PDGF) and its receptor β (PDGFRβ) play a major role in hepatic stellate cells activation and are, therefore, promising targets for antifibrotic therapies. Gold nanorods hold great potential for diseased liver treatments, since their passive hepatic accumulation enhances active targeting strategies, hence increasing therapeutic efficiency. In addition, gold nanorods have photothermal properties that, combined with specific cell delivery, can be exploited to induce localized near-infrared light-mediated thermal ablation. Here, we demonstrate that gold nanorods coated with anti-PDGFRβ specifically target activated hepatic stellate cells in vivo. Additionally, gold nanorods-PDGFRβ-mediated photothermal therapy decreases fibrosis, hepatic inflammation, and hepatocyte injury in the experimental model of CCl4-induced liver fibrosis in mice. |
| Databáze: | OpenAIRE |
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