Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two-year-old child
| Autor: | Wolfgang Muntean, Albrecht Beitzke, Gerfried Zobel, K. Finding, W Zenz |
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| Rok vydání: | 1994 |
| Předmět: |
Heart Septal Defects
Ventricular Male medicine.medical_specialty medicine.medical_treatment Subclavian Artery Fibrin Tissue Adhesive Pulmonary Artery Gastroenterology Fibrin Thrombin Postoperative Complications Internal medicine Medicine Animals Humans biology business.industry Anastomosis Surgical Factor V General Medicine Blood Coagulation Disorders Surgery Cardiac surgery Transplantation Child Preschool Pediatrics Perinatology and Child Health Toxicity biology.protein Plasmapheresis Cattle business Complication medicine.drug |
| Zdroj: | Acta paediatrica (Oslo, Norway : 1992). 83(1) |
| ISSN: | 0803-5253 |
| Popis: | Muntean W, Zenz W, Finding K, Zobel G, Beitzke A. Inhibitor to factor V after exposure to fibrin sealant during cardiac surgery in a two-year-old child. Acta Prediatr 1994;83:84–7. Stockholm. ISSN 0803–5253 A two-year-old infant developed an inhibitor to factor V after cardiac surgery, with application of fibrin sealant containing bovine thrombin. Investigation of this inhibitor by means of inhibition experiments and immunoblot analysis revealed that the inhibitor reacted strongly with bovine, but only weakly with human factor V. Plasmapheresis proved effective in increasing factor V levels. This patient provides further evidence that exposure to topical thrombin preparations may lead to the development of inhibitors in the postoperative period that may cause bleeding complications. |
| Databáze: | OpenAIRE |
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