Vitamin D status and oxidative stress in diabetes mellitus
| Autor: | Seetha Munisamy, Sahran Yahaya, Siti Safiah Mokhtar, Aida Hanum Ghulam Rasool, Wee Chee Lee |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant Free Radicals medicine.medical_treatment Endogeny medicine.disease_cause Diabetes Mellitus Experimental Pathogenesis 03 medical and health sciences 0302 clinical medicine Chronic hyperglycemia Diabetes mellitus Internal medicine medicine Vitamin D and neurology Animals Humans Significant risk Vitamin D 030102 biochemistry & molecular biology business.industry General Medicine medicine.disease Rats Oxidative Stress Endocrinology Diabetes Mellitus Type 2 business Reactive Oxygen Species 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | Cellular and molecular biology (Noisy-le-Grand, France). 64(7) |
| ISSN: | 1165-158X |
| Popis: | Diabetes mellitus is an epidemic that is gaining global concern. Chronic hyperglycemia in diabetes induces the excess production of free radicals. The deleterious effects of excess free radicals are encountered by endogenous antioxidant defense system. Imbalance between free radicals production and antioxidants defense mechanisms leads to a condition known as "oxidative stress”. Diabetes mellitus is associated with augmented oxidative stress that induced micro- and macrovascular complications, which presents a significant risk for cardiovascular events. Low vitamin D levels in the body have also been reported to be associated with the pathogenesis of diabetes and enhanced oxidative stress. The article is to review available literature and summarize the relationship between oxidative stress and vitamin D levels in diabetes. We also review the effects of vitamin D analogs supplementation in improving oxidative stress in diabetics. |
| Databáze: | OpenAIRE |
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