Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism
| Autor: | Evangelina Giacoia, Adriana Graciela Díaz, Luisina Pieroni, H. Salerni, Beatriz Oliveri, A.M. Galich, Betiana Perez, Damian Robbiani, Silvina Tormo, Sabrina Lucas, Adriana Frigeri, Ariela Kitaigrodsky, María Auxiliadora Arce Lange, Silvia Kallsbrum, María Belén Zanchetta |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Context (language use) Disease hypocalcemia HYPOCALCEMIA 03 medical and health sciences Hyperphosphatemia 0302 clinical medicine purl.org/becyt/ford/3.2 [https] medicine hyperphosphatemia HYPERPHOSPHATEMIA Clinical Research Articles HYPOPARATHYROIDISM business.industry Thyroid disease hypoparathyroidism medicine.disease Natural history 030104 developmental biology Hypoparathyroidism Etiology purl.org/becyt/ford/3 [https] business AcademicSubjects/MED00250 PTH Rare disease |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| Popis: | Context:Hypoparathyroidism is a rare disease and as such, its natural history, long term complications and correct clinical management remain unclear.ObjectiveTo describe the natural history and clinical characteristics of the disease.Design and settingTopresent a retrospective observational analysis from seven specialized centers in Buenos Aires, Argentina.Patientschronic hypoparathyroid patients followed up between 1985 and December 2018.Main Outcome Measuresdata on demographics, etiology, clinical complications, biochemical parameters, DXA values and treatment doses were collected.Results322 subjects with chronic hypoparathyroidism were included, 85.7 % were female. Mean age was 55.2 ± 16.8 years and mean age at diagnosis was 43.8 ± 16.8. Prevalence of surgical hypoparathyroidism was 90.7 %, most common causes being thyroid carcinoma and benign thyroid disease. A history of hypocalcemia requiring hospitalization was present in 25.7 % and 4.3 % had a history of seizures. Overall, 40.9 % had reported at least one neuromuscular symptom. Renal insufficiency was present in 22.4 % and was significantly associated with age (p |
| Databáze: | OpenAIRE |
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