Inverse relationship between high-density lipoprotein cholesterol raising and high-sensitivity C-reactive protein reduction in older patients treated with lipid-lowering therapy
| Autor: | JoAnne M. Foody, W. Virgil Brown, Franklin J. Zieve, Andrew M. Tershakovec, Arvind Shah, Joanne E. Tomassini |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Endocrinology Diabetes and Metabolism Atorvastatin chemistry.chemical_compound High-density lipoprotein Ezetimibe Internal medicine Internal Medicine Humans Medicine cardiovascular diseases Aged Apolipoproteins B Aged 80 and over Nutrition and Dietetics biology business.industry Cholesterol Anticholesteremic Agents Cholesterol HDL C-reactive protein nutritional and metabolic diseases Cholesterol LDL C-Reactive Protein Endocrinology chemistry Simvastatin biology.protein Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business human activities medicine.drug Lipoprotein |
| Zdroj: | Journal of Clinical Lipidology. 10:116-123 |
| ISSN: | 1933-2874 |
| DOI: | 10.1016/j.jacl.2015.10.002 |
| Popis: | Background Little is known regarding relationships between high-sensitivity C-reactive protein (hsCRP) and lipoproteins other than low-density lipoprotein cholesterol (LDL-C). High-density lipoprotein (HDL), with both anti-inflammatory and cholesterol-mediating effects, is of particular interest. This exploratory analysis assessed associations between hsCRP and lipids in older (>65 years) patients with moderate and/or high cardiovascular disease risk, before and after treatment with ezetimibe/simvastatin (E/S) or atorvastatin (ATV). Methods An analysis of a multicenter, randomized, double-blind, 12-week study. Correlations were assessed in 1054 patients with both baseline and 12-week hsCRP ≤10 mg/L, pooled across doses of E/S (10/20 and 10/40 mg) and ATV (10, 20, and 40 mg), and combined E/S + ATV treatments. Because of multiple comparisons, observed relationships were considered significant only if P values were Results Correlations between baseline levels of hsCRP and either LDL-C, non–HDL-C, or apolipoprotein B were weak and nonsignificant in the E/S, ATV, and E/S + ATV groups. After 12 weeks of treatment, these correlations increased slightly and significantly in all groups, except for LDL-C in the ATV group. HDL-C was significantly but inversely correlated with hsCRP in the ATV and E/S + ATV groups at baseline, and in all groups at 12 weeks. Only with HDL-C did change correlate with change in hsCRP in both the E/S and combined groups. Conclusions Relationships between hsCRP and lipid factors in older patients were weak at baseline and somewhat stronger after treatment. HDL-C was inversely and consistently correlated with baseline and 12-week on-treatment hsCRP and with therapy-induced changes in HDL-C and hsCRP. |
| Databáze: | OpenAIRE |
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