An illustration of the use of isotopes: The biosynthesis of porphyrins

Autor:	David Shemin
Rok vydání:	1989
Předmět:	Porphyrins Nitrogen Isotopes Blood proteins General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Biochemistry Biosynthesis chemistry Isotope Labeling Glycine Chlorophyll synthesis Humans Carbon Radioisotopes Hemoglobin Vitamin B12 Heme
Zdroj:	BioEssays. 10:30-35
ISSN:	1521-1878 0265-9247
DOI:	10.1002/bies.950100108
Popis:	In this article, David Shemin, who is now in retirement, describes how in 1944 he ingested 66 g of 15N-labeled glycine in order to determine the half-life of hemoglobin and other blood proteins. The ramifications of the experiment led to the unravelling of the biosynthesis of porphyrins and the role of glycine and alpha-aminolevulinic acid in heme, vitamin B12 and chlorophyll synthesis.
Databáze:	OpenAIRE
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