Biomechanical Properties of Cancer Cells
| Autor: | Noémie Lopez-Ramirez, Ingrid Masse, Gaël Runel, Julien Chlasta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Optical Tweezers Tumor cells Review 02 engineering and technology Cell Communication Biology Cell morphology Microscopy Atomic Force Mechanotransduction Cellular biomechanics Extracellular matrix 03 medical and health sciences Cell Movement Neoplasms medicine Tumor Cells Cultured Tumor Microenvironment Humans cancer Tumor growth Neoplasm Invasiveness lcsh:QH301-705.5 Cytoskeleton Viscosity Cancer General Medicine Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology medicine.disease Molecular biomarkers Elasticity Extracellular Matrix 030104 developmental biology Cell Transformation Neoplastic lcsh:Biology (General) Cancer cell biomarker Cancer development 0210 nano-technology Neuroscience |
| Zdroj: | Cells, Vol 10, Iss 887, p 887 (2021) Cells |
| ISSN: | 2073-4409 |
| Popis: | Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have actually been proposed as promising biomarkers for cancer diagnosis and prognosis. The present review first describes the main methods used to study the mechanical properties of cancer cells. Then, we address the nanomechanical description of cultured cancer cells and the crucial role of the cytoskeleton for biomechanics linked with cell morphology. Finally, we depict how studying interaction of tumor cells with their surrounding microenvironment is crucial to integrating biomechanical properties in our understanding of tumor growth and local invasion. |
| Databáze: | OpenAIRE |
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