Tranexamic Acid-Induced Acute Renal Cortical Necrosis in Post-Endoscopic Papillectomy Bleeding
| Autor: | Baek Hyun Yoon, Jong Wook Kim, Seung Goun Hong, Ji Hong Oh, Doo Hyun Ko, Ja Joong Gu, Tae Hyung Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Gastrointestinal bleeding Tranexamic acid lcsh:Internal medicine Antifibrinolytic medicine.drug_class medicine.medical_treatment 030232 urology & nephrology Medicine (miscellaneous) Case Report Hemorrhage Endoscopic papillectomy 03 medical and health sciences 0302 clinical medicine Oliguria medicine Radiology Nuclear Medicine and imaging lcsh:RC799-869 lcsh:RC31-1245 Dialysis business.industry Gastroenterology Pulmonary edema medicine.disease Kidney cortex necrosis Surgery Anesthesia 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology Hemodialysis medicine.symptom Kidney Cortex Necrosis business medicine.drug |
| Zdroj: | Clinical Endoscopy, Vol 50, Iss 6, Pp 609-613 (2017) Clinical Endoscopy |
| ISSN: | 2234-2443 2234-2400 |
| Popis: | Acute renal failure can be the result of acute renal cortical necrosis (RCN), which commonly occurs from complications occurring during pregnancy. RCN is rarely caused by medications, although tranexamic acid, which is used in patients with acute bleeding for its antifibrinolytic effects, reportedly causes acute RCN in rare cases. An 82-year-old woman experienced gastrointestinal bleeding after endoscopic papillectomy of an ampullary adenoma. The bleeding was controlled with tranexamic acid administration; however, 4 days later, her urine volume decreased and she developed pulmonary edema and dyspnea. Serum creatinine levels increased from 0.8 to 3.9 mg/dL and dialysis was performed. Abdominal pelvic computed tomography with contrast enhancement revealed bilateral RCN with no renal cortex enhancement. Renal dysfunction and oliguria persisted and hemodialysis was continued. Clinicians must be aware that acute RCN can occur after tranexamic acid administration to control bleeding. |
| Databáze: | OpenAIRE |
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