Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows
| Autor: | Marcelo Gil Araujo, Heinrich Bollwein, M. Heppelmann, C. Pfarrer, Hans-Joachim Schuberth, Anja Sipka, Marion Piechotta, Lars C. Holzhausen |
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| Přispěvatelé: | University of Zurich, Piechotta, M |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Thyroid Hormones
medicine.medical_specialty medicine.medical_treatment 3400 General Veterinary Suppressor of Cytokine Signaling Proteins Growth hormone receptor Biology suppressor of cytokine signaling Insulin-like growth factor Pregnancy Internal medicine medicine Animals Insulin Endocrine system SOCS2 Progesterone Dairy cattle Estradiol General Veterinary 630 Agriculture insulin-like growth factor I 10187 Department of Farm Animals Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Endocrinology Insulin-Like Growth Factor Binding Protein 4 Liver cattle Hormone receptor Growth Hormone Pregnancy Animal 570 Life sciences biology Original Article Female metabolism Postpartum period |
| Zdroj: | Journal of Veterinary Science |
| DOI: | 10.5167/uzh-107162 |
| Popis: | Cows with different Insulin-like Growth Factor-I (IGF-I) concentrations showed comparable expression levels of hepatic growth hormone receptor (GHR). Suppressor of cytokine signaling 2 (SOCS2), could be responsible for additional inhibition of the GHR signal cascade. The aims were to monitor cows with high or low antepartal IGF-I concentrations (IGF-I(high) or IGF-I(low)), evaluate the interrelationships of endocrine endpoints, and measure hepatic SOCS2 expression. Dairy cows (n = 20) were selected (240 to 254 days after artificial insemination (AI)). Blood samples were drawn daily (day -17 until calving) and IGF-I, GH, insulin, thyroid hormones, estradiol, and progesterone concentrations were measured. Liver biopsies were taken (day 264 ± 1 after AI and postpartum) to measure mRNA expression (IGF-I, IGFBP-2, IGFBP-3, IGFBP-4, acid labile subunit (ALS), SOCS2, deiodinase1, GHR1A). IGF-I concentrations in the two groups were different (p0.0001). However, GH concentrations and GHR1A mRNA expression were comparable (p0.05). Thyroxine levels and ALS expression were higher in the IGF-I(high) cows compared to IGF-I(low) cows. Estradiol concentration tended to be greater in the IGF-I(low) group (p = 0.06). It was hypothesized that low IGF-I levels are associated with enhanced SOCS2 expression although this could not be decisively confirmed by the present study. |
| Databáze: | OpenAIRE |
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